Table 2.
Mediation of the association between malaria in pregnancy and antepartum stillbirth or neonatal death
| Mediating variable/s | Natural indirect effect, risk ratio (95% CI) | Natural direct effect, risk ratio (95% CI) | Proportion indirect |
|---|---|---|---|
| Falciparum malaria and antepartum stillbirth | |||
| SGA only | 1.09 (1.05, 1.14) | 1.61 (0.84, 2.67) | 18% |
| Maternal anaemia and SGA | 1.23 (1.15, 1.34) | 1.48 (0.77, 2.46) | 42% |
| Symptomatic vivax malaria and antepartum stillbirth | |||
| SGA only | 1.10 (1.04, 1.17) | 1.91 (0.65, 3.49) | 16% |
| Maternal anaemia and SGA | 1.13 (1.06, 1.23) | 1.73 (0.59, 3.20) | 24% |
| Falciparum malaria and neonatal death | |||
| Preterm birth only | 1.25 (1.10, 1.43) | 2.27 (1.29, 3.63) | 26% |
| SGA and preterm birth | 1.30 (1.15, 1.49) | 1.82 (1.07, 2.89) | 40% |
| Vivax malaria and neonatal death | |||
| Preterm birth only | 1.20 (1.05, 1.37) | 1.58 (0.94, 2.44) | 31% |
| SGA and preterm birth | 1.25 (1.09, 1.44) | 1.32 (0.81, 1.98) | 50% |