Table 2.

Multivariate analysis of risk factors associated with overall and disease-free survival

Variable (risk)	HR	[95% CI]	P
Overall survival
General factor
Sex (male)	2.262	[0.746–8.336]	0.153
Primary colorectal cancer related factors
Location (rectum)	2.042	[0.698–6.344]	0.193
N stage (N2)	1.422	[0.402–4.455]	0.566
Lung metastasis related factors
Preoperative serum CEA (≥5.0 ng/mL)	3.793	[1.292–11.955]	0.015
DFI after colorectal cancer resection (<24 months)	6.424	[1.708–42.585]	0.004
Disease-free survival
General factor
Sex (male)	1.929	[0.893–4.352]	0.095
Primary colorectal cancer related factors
N stage (N2)	3.106	[1.232–7.231]	0.018
Vascular invasion (identified)	2.395	[0.769–10.536]	0.141
Lung metastasis related factors
Tumor distribution (bilateral)	2.227	[0.720–6.147]	0.156
Preoperative serum CEA (≥5.0 ng/mL)	1.977	[0.869–4.462]	0.103
DFI after colorectal cancer resection (<24 months)	2.838	[1.271–7.224]	0.010

CEA carcinoembryonic antigen, CI confidence interval, DFI disease-free interval, HR hazard ratio