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Single dose methotrexate (MTX) for treatment of ectopic pregnancy
| Day 1 | Day 4 | Day 7 | |
|---|---|---|---|
| Labs | 1. β-hCG | β-hCG | 1. β-hCG |
| 2. Safety labs (complete blood count, BUN, creatinine, AST, ALT) | 2. Safety labs | ||
| 3. Blood type and antibody screen | |||
| Action | Give MTX (50 mg/m2 of body surface area IM) | no action | β-hCG decline <15 % from Day 4 to Day 7: MTX, return to day 1 of protocol. Repeat MTX up to a total of 4 doses |
| β-hCG decline >15 %: Check β-hCG at 1 week intervals until zero. |
