Table 4.
Multiple dose methotrexate (MTX) and leucovorin (LEU) for treatment of ectopic pregnancy
| Day 1 | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | Day 8 | |
|---|---|---|---|---|---|---|---|---|
| Labs | 1. β-hCG | β-hCG | β-hCG | β-hCG | ||||
| 2. Safety labs (complete blood count, BUN, creatinine, AST, ALT) | ||||||||
| 3. Blood type and antibody screen | ||||||||
| Action | MTX (1 mg/kg, IM) | LEU (0.1 mg/kg, IM) | β-hCG decline <15 % from Day 1 to Day 3: Give MTX | LEU | β-hCG decline <15 % from Day 3 to Day 5: Give MTX | LEU | β-hCG decline <15 % from Day 5 to Day 7: Give MTX | LEU |
| β-hCG decline >15 % from Day 1 to Day 3: Check β-hCG at one week intervals until zero. | β-hCG decline >15 % from Day 3 to Day 5: Check β-hCG at one week intervals until zero. | β-hCG decline >15 % from Day 5 to Day 7: Check β-hCG at one week intervals until zero. |