Table 2. Substrate Scope and Limitations in the One-Pot Tetrazolopiperidinone Reaction^a.

^aIsolated yields are shown. Diastereomeric ratios (dr) were determined by SFC-MS and ¹H NMR analyses.

^bThe diastereomeric mixture was isolated in 9:1 dr.

^cThe cis:trans ratio was 4:1.

^dThe diastereomeric mixture was isolated in 1:1:0.1:0.1 dr.

^eThe diastereomeric mixture was isolated in 4:3 dr.

^fThe cis:trans ratio was 19:1.