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Model for replication-dependent, incision-independent repair of a psoralen-derived interstrand cross-link. (a) CMG helicase stalls at cross-link. (b) NEIL3 unhooks the cross-link. (c) TLS and extension past the Ap site and psoralen adduct remnant. (d) Repair of the Ap site by a pathway involving APE, pol β, and ligase III (upper duplex) and NER or BER to remove the psoralen cross-link remnant (lower duplex).
