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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: DNA Repair (Amst). 2017 Feb 20;52:1–11. doi: 10.1016/j.dnarep.2017.02.011

Figure 4.

Figure 4

Formation and structure of a psoralen-derived interstrand cross-link. Panel A: Two sequential photoinduced [2+2] cycloaddition reactions generate interstrand cross-links preferentially at 5′-TA sequences in duplex DNA. The reaction is shown for the psoralent derivative trioxsalen. Panel B: The three-dimensional structure of a psoralen-derived cross-link in duplex DNA. Thymine residues are shown with carbons colored yellow and psoralen with carbons colored in gray (image prepared by modification of pdb 204d).