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Model for replication-dependent, incision-independent repair of an Ap-derived interstrand cross-link. (a) NEIL3 unhooking of the cross-link by cleavage of the non-native glycosidic bond. (b) TLS and extension past the Ap site and normal extension past the native adenine residue. Repair of the Ap-containing duplex may be completed by the BER proteins APE, pol β, and DNA ligase.
