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The effect of hesperetin on the interleukin-6 expression. Expression of interleukin-6 was significantly upregulated in PC3 being treated with hesperetin at the concentrations of 400, 450, and 500 μM after 48 h in a dose-dependent pattern. mRNA expression of interleukin-6 normalized with glyceraldehyde-3-phosphate dehydrogenase as an internal control. aP < 0.05 compared to the control cells. bP < 0.05 compared to 400 μM hesperetin-treated PC3 cells
