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The effects of hesperetin on the level of signaling pathway proteins in PC3 cells which were treated with increasing doses of hesperetin for 48 h, and cell lysates were collected and subjected to Western blotting analysis. Equal amounts of lysate protein were subjected to gel electrophoresis. Hesperetin upregulated the expression of phosphorylated signal transducer and activator of transcription 3, pAKT, and phosphorylated extracellular signal-regulated kinases 1/2
