FIGURE 1.

Typical atopic dermatitis lesions in domestic animals and humans versus NC/Tnd mice. Atopic lesions in a Maltese dog's ear (a) and subaxillary (b); itchy atopic dermatitis (neurodermitis) in a child (d) and in flexural site of a human adult (e); on ear and around the eye of a horse (c, f) (a–f from [3], reproduced with permission of Springer); (g) in an NC/Tnd mouse an inbred strain originating from NC/Nga, modeling all features of natural atopic dermatitis including barrier leakage and itchiness (by courtesy of Professor Hiroshi Matsuda, Tokyo University of Agriculture and Technology, Japan).