Table 1.

Neuropeptide families^* and migraine.

Families possibly involved in migraine+	Other families
CGRP: CGRP (α, β), calcitonin, amylin, adrenomedullin (AM1,2)	Opioids: enkephalins, dynorphin, endorphins, nociceptin
	Somatostatin/cortistatin
Glucagon/secretin: PACAP, VIP, glucagon, secretin, GHRH, GIP	Natriuretic factors: ANF, BNF, CNP
	GRP, neuromedins
Vasopressin/oxytocin	Endothelins
	CCK/gastrin
F- and Y-amides: NPY, PPY, NPFF	Insulins: insulin, IGFs, relaxins
	Motilin/ghrelin
Tachykinins: Sub P, neurokinin A, neuropeptide K, neuropeptide gamma	Galanins
	Gonadotropin releasing hormones
Tensins: angiotensin, neurotensin, bradykinin	Neuropeptide B/W/S
	Neurexophilins
CRH-related: CRH, urocortins, urotensins	Cerebellins
	Granins: chromogranins, secretogranins
Adipose neuropeptides: leptin, adiponectin, resistins
Family-less: orexins, MCH, TRH, PTHrP, CART, AGRP, prolactin, diazepam-binding inhibitor peptide, kisspeptins, etc

^*For full list of family members, see: http://www.neuropeptides.nl/tabel%20neuropeptides%20linked.htm

⁺neuropeptides that may potentially be involved in migraine pathogenesis are indicated in bold.