Figure 5.

CPS-C increases oxaliplatin-induced changes in protein levels of the PI3K/Akt/mTOR pathway in ESCC cell lines TE-1 (A) and TE-2 (B). Protein levels were detected using Western blotting analysis. Oxaliplatin combined with CPS-C decreased the expressions of PI3K, phospho-Akt, phospho-mTOR, Bcl-2, and Bcl-XL, but increased the expression of Bax and caspase-3 significantly compared to oxaliplatin-only treatment, while no differences were observed in either the CPS-C group or the control group (P>0.05).