Table 10.

P values testing Hardy–Weinberg proportion and test for heterogeneity of studies included in the meta-analysis for FokI ff polymorphism respectively.

Study	Intervention	Controls	Odds ratio	95% CI	z	P
Balazs Gyorffy 2002	22/107	18/103	1.222	0.612–2.441
Tatijana Semunik 2005	29/132	23/232	2.558	1.410–4.643
J J San Pedro 2005	5/71	8/88	0.758	0.237–2.426
C Panierakis 2009	1/100	7/96	0.128	0.0155–1.064
Greear R M 2013	7/55	5/50	1.312	0.388–4.435
Total (fixed effects)	64/465	61/569	1.374	0.943–2.003	1.656	0.098
Total (random effects)	64/465	61/569	1.159	0.573––2.344	0.411	0.681
Q	10.1246
DF	4
Significance level	P = 0.0384
I2 (inconsistency)	60.49%
95% CI for I2	0.00–85.20

Bias indicators: Begg–Mazumdar: Kendall’s Tau = −0.6 P = 0.0833 (low power); Egger: bias = −3.173487 (95% CI = −6.536026 to 0.189052) P = 0.575; Harbord–Egger: bias = −4.109035 (92.5% CI = −8.5417147 to 0.323644) P = 0.0889.

DF, degree of freedom; Q, heterogeneity in meta analysis.