Table 3.

P values testing Hardy–Weinberg proportion and test for heterogeneity of studies included in the meta-analysis for ApaI Aa polymorphism respectively.

Study	Intervention	Controls	Odds ratio	95% CI	z	P
T J Chang 2000	76/157	105/248	1.278	0.855–1.910
Balazs Gyorffy 2002	45/107	54/103	0.659	0.382–1.136
Vaselin Scrabic 2003	52/134	66/132	0.634	0.390–1.032
J J San Pedro 2005	37/71	43/88	1.139	0.609–2.129
Diego Garcia 2007	115/216	125/203	0.710	0.481–1.048
C Panierakis 2009	58/100	57/96	0.945	0.535–1.669
Greear R M 2013	24/55	32/50	0.435	0.198–0.956
Chung Cheon 2015	32/81	34/113	1.517	0.833–2.765
Total (fixed effects)	439/921	516/1033	0.873	0.729–1.046	−1.473	0.141
Total (random effects)	439/921	516/1033	0.866	0.664–1.131	−1.054	0.292
Q	14.2512
DF	7
Significance level	P = 0.0469
I2 (inconsistency)	50.88%
95% CI for I2	0.00–78.02

Bias indicators: Begg–Mazumdar: Kendall’s Tau = 0 P = 0.9049 (low power); Egger: bias = −0.928241 (95% CI = −7.113964 to 5.257482) P = 0.7261; Harbord–Egger: bias = −0.806491 (92.5% CI = −6.321591 to 4.708608) P = 0.7638.

DF, degree of freedom; Q, heterogeneity in meta analysis.