Table 7.
P values testing Hardy–Weinberg proportion and test for heterogeneity of studies included in the meta-analysis for BsmI bb polymorphism, respectively.
Study | Intervention | Controls | Odds ratio | 95% CI | z | P |
---|---|---|---|---|---|---|
T J Chang 2000 | 137/157 | 231/248 | 0.504 | 0.255–0.995 | ||
Balazs Gyorffy 2002 | 35/107 | 40/103 | 0.766 | 0.435–1.348 | ||
Vaselin Scrabic 2003 | 52/134 | 41/132 | 1.407 | 0.848–2.336 | ||
J J San Pedro 2005 | 16/71 | 27/88 | 0.657 | 0.321–1.347 | ||
Diego Garcia 2007 | 77/216 | 115/203 | 0.424 | 0.286–0.628 | ||
C Panierakis 2009 | 15/100 | 20/96 | 0.671 | 0.321–1.402 | ||
Chung Cheon 2015 | 68/81 | 108/113 | 0.242 | 0.0826–0.710 | ||
Total (fixed effects) | 400/866 | 582/983 | 0.632 | 0.508–0.786 | −4.114 | <0.001 |
Total (random effects) | 400/866 | 582/983 | 0.624 | 0.418–0.933 | −2.298 | 0.022 |
Q | 17.5208 | |||||
DF | 6 | |||||
Significance level | P = 0.0075 | |||||
I2 (inconsistency) | 65.76% | |||||
95% CI for I2 | 23.26–84.72 |
Bias indicators: Begg–Mazumdar: Kendall’s Tau = −0.142857 P = 0.5619 (low power); Egger: bias = −0.656941 (95% CI = −7.053883 to 5.74) P = 0.8023; Harbord–Egger: bias = 0.561504 (92.5% CI = −6.312289 to 5.189281) P = 0.8354.
DF, degree of freedom; Q, heterogeneity in meta analysis.