Skip to main content
. Author manuscript; available in PMC: 2017 Sep 20.
Published in final edited form as: Nat Med. 2017 Mar 20;23(4):472–482. doi: 10.1038/nm.4310

Figure 5. Genetic or chemical inhibition of c-Fos and Dusp1 downregulates the Fos-Jun network while activating Jun-JunD target genes.

Figure 5

a. Heat map showing commonly modulated genes in BCR-ABL expressing Kit+ cells with c-Fos and Dusp1 deletion and wild type cells treated with Fos (DFC) and Dusp1 (BCI) inhibitors alone or with imatinib. Genetic and chemical inhibition resulted in modulation of 146 genes in common (58 overexpressed and 88 under expressed). b and c. Netwalker analysis shows that overexpressed genes are enriched for genes participating in a Jun-JunD regulated network (b), while downregulated genes are enriched for genes participating in a Fos-Jun regulated network (c).