Table 1A.
Partitioned Survival | Distribution | Coefficient | SE | HR (95%) CI | P Value |
---|---|---|---|---|---|
Progression-free survival
(event: progression or death) |
Weibull | ||||
Treatment: RFC v. FC | −0.519 | 0.117 | 0.595 (0.473, 0.748) | <0.001 | |
Log(scale) | 1.237 | 0.060 | |||
Log(shape) | 0.310 | 0.051 | |||
Overall survival
(event: death with or without progression) |
|||||
Observed period (0–3.6 years) | Exponential | ||||
Treatment: RFC v. FC | −0.284 | 0.204 | 0.753 (0.505, 1.123) | 0.164 | |
Log(scale) | 2.753 | 0.137 | |||
Extrapolation (3.6–15 years)a | |||||
Weibull shape | 2.257 | 0.484 | |||
Weibull log(scale) | −4.377 | 0.659 |
Derived from a linear regression using the approach described elsewhere.16