Table 2.

List of the top genes down-regulated by [Ca²⁺]_o treatment: Top 10 for each time point. p value assed based on pair-wise comparisons with the untreated controls using Student's t-test (two sided, unpaired, assuming unequal variances).

Name	Symbol	Fold change	p-Value
Decreased after 1 h
DNA-damage-inducible transcript 4	DDIT4	−2.265	0.0048
Ring finger protein 186	RNF186	−1.807	0.0000
Stanniocalcin 2	STC2	−1.531	0.0022
Protein phosphatase 2regulatory subunit B, alpha isoform	PPP2R2A	−1.505	0.0069
Hematopoietically expressed homeobox	HHEX	−1.455	0.0086
Forkhead box P1	FOXP1	−1.427	0.0016
Stanniocalcin 1	STC1	−1.343	0.0013
Polymerase (DNA directed), theta	POLQ	−1.333	0.0044
Solute carrier family 30 (zinc transporter), member 1	SLC30A1	−1.319	0.0046
Kinesin family member 15	KIF15	−1.313	0.0148
Decreased after 4 h
Metallothionein 1X	MT1X	−1.720	0.00754
Metallothionein 1F	MT1F	−1.713	0.00429
Jun oncogene	JUN	−1.688	0.00075
Activating transcription factor 3	ATF3	−1.675	0.00011
Meiotic nuclear divisions 1 homolog (S. cerevisiae)	MND1	−1.554	0.00082
Tensin 1	TNS1	−1.544	0.00021
Denticleless homolog (Drosophila)	DTL	−1.504	0.00740
Cell division cycle 6 homolog (S. cerevisiae)	CDC6	−1.497	0.00285
Achaete-scute complex homolog 2 (Drosophila)	ASCL2	−1.488	0.00033
Decreased after 24 h
Transgelin	TAGLN	−7.575	7.10E−06
Asparagine synthetase	ASNS	−4.283	9.94E−07
E2F transcription factor 7	E2F7	−3.947	1.82E−03
Denticleless homolog (Drosophila)	DTL	−3.653	3.61E−05
Solute carrier family 7, (cationic amino acid transporter, y + system) member 11	SLC7A11	−3.580	8.37E−04
Metallothionein 1F	MT1F	−3.552	3.62E−05
Metallothionein 1X	MT1X	−3.414	9.34E−06
Minichromosome maintenance complex component 10	MCM10	−3.349	6.85E−05
Phosphoserine aminotransferase 1	PSAT1	−3.309	4.66E−05
Cell division cycle 6 homolog (S. cerevisiae)	CDC6	−3.090	7.49E−06