Table 4.
Top biological functions and canonical pathways in Ingenuity (www.ingenuity.com) affected after 24 h treatment with 2 mM [Ca2+]o.
| Category | Term | p-Value | No. of molecules |
|---|---|---|---|
| Top biological functions: Diseases and disorders | |||
| Cancer | 2.25E−04−3.32E−19 | 720 | |
| Organismal injury and abnormalities | 2.25E−04−3.32E−19 | 723 | |
| Reproductive system disease | 1.99E−04−2.21E−16 | 422 | |
| Gastrointestinal disease | 1.99E−04−5.05E−14 | 634 | |
| Endocrine system disorders | 1.54E−04−9.90E−11 | 158 | |
| Molecular and cellular functions | |||
| Cell cycle | 2.18E−04−1.05E−28 | 224 | |
| Cellular growth and proliferation | 2.30E−04−6.58E−26 | 336 | |
| Cell death and survival | 2.21E−04−3.03E−24 | 334 | |
| DNA replication, recombination, and repair | 2.35E−04−6.28E−20 | 183 | |
| Cellular development | 2.18E−04−6.02E−14 | 272 | |
| Physiological system development and function | |||
| Organismal survival | 1.94E−05−4.02E−16 | 234 | |
| Connective tissue development and function | 2.18E−04−1.74E−09 | 128 | |
| Tissue development | 2.30E−04−1.74E−09 | 141 | |
| Embryonic development | 1.99E−04−8.84E−08 | 161 | |
| Organismal development | 1.99E−04−4.25E−07 | 199 | |
| Top canonical pathways: | Overlap | ||
| Cell cycle control of chromosomal replication | 1.01E−17 | 50% | |
| Role of BRCA1 in DNA damage response | 5.22E−14 | 28.2% | |
| Estrogen-mediated S-phase Entry | 1.15E−11 | 50% | |
| Mismatch repair in eukaryotes | 3.12E−11 | 62.5% | |
| Hereditary breast cancer signaling | 8.84E−11 | 17.6% |