Table 3.
Association of ancestry with glycaemia, adjusted for obesity and social factors, in 1,387 non-diabetic individuals
| Characteristic | FG
|
HbA1c
|
||||||
|---|---|---|---|---|---|---|---|---|
| Model 2
|
Model 3
|
Model 2
|
Model 3
|
|||||
| Estimatea | p valueb | Estimate | p value | Estimate | p value | Estimate | p value | |
| Intercept, mmol/l or % HbA1c | 5.62 | 5.82 | 5.49 | 5.47 | ||||
| European ancestry | −0.0014 | 0.05 | −0.0019 | 0.02 | −0.0024 | < 0.001 | −0.0021 | <0.001 |
| Native American ancestry | −0.0029 | 0.06 | −0.0035 | 0.02 | 0.0004 | 0.57 | 0.0001 | 0.90 |
| Age, years | ||||||||
| 34–44 | Ref. | Ref. | Ref. | Ref. | ||||
| 45–54 | 0.356 | 0.78 | 0.162 | 0.89 | 0.073 | 0.005 | 0.068 | 0.009 |
| 55–64 | 1.736 | 0.16 | 1.387 | 0.25 | 0.147 | < 0.001 | 0.142 | < 0.001 |
| 65–74 | 2.416 | 0.11 | 1.926 | 0.2 | 0.252 | < 0.001 | 0.242 | < 0.001 |
| 75–87 | 0.787 | 0.69 | 0.529 | 0.76 | 0.318 | < 0.001 | 0.291 | < 0.001 |
| Male sex | 0.435 | 0.66 | 0.232 | 0.81 | −0.016 | 0.48 | −0.022 | 0.31 |
| BMI, kg/m2 | ||||||||
| <25 | Ref. | Ref. | Ref. | Ref. | ||||
| 25–30 | 0.304 | 0.78 | 0.244 | 0.82 | 0.101 | < 0.001 | 0.096 | < 0.001 |
| ≥30 | 3.284 | 0.003 | 3.421 | 0.002 | 0.186 | < 0.001 | 0.180 | < 0.001 |
| Income, US$ | ||||||||
| <20,000 | −0.010 | 1.00 | 0.008 | 0.84 | ||||
| 20,000–49,999 | 0.374 | 0.77 | 0.054 | 0.09 | ||||
| ≥50,000 | Ref. | Ref. | ||||||
| Education | ||||||||
| Less than high school | −2.362 | 0.14 | 0.065 | 0.22 | ||||
| High school or equivalent | −3.965 | 0.006 | 0.009 | 0.76 | ||||
| Some college | −2.751 | 0.07 | −0.002 | 0.95 | ||||
| College or more | Ref. | Ref. | ||||||
| Occupation | ||||||||
| Professional | Ref. | Ref. | ||||||
| Service | 0.662 | 0.63 | −0.016 | 0.61 | ||||
| Manual labour | 2.349 | 0.19 | 0.056 | 0.18 | ||||
| Never worked | 5.266 | 0.005 | −0.046 | 0.27 | ||||
| Private insurance vs public/other | −2.357 | 0.09 | −0.015 | 0.65 | ||||
To convert values for HbA1c in % into mmol/mol, subtract 2.15 and multiply by 10.929
Changes in FG (mmol/l) or HbA1c (%) per 1% change in AIMs proportion from 100% African ancestry
p value that change in FG or HbA1c not = 0
Ref., reference group