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Schematic representation of different antibody formats. The combination of the variable regions of 2 monoclonal antibodies (A) can be achieved via numerous bispecific antibody formats (B). Here exemplified is a single chain variable fragment fusion to an IgG (scFv-IgG), a dual-affinity retargeting immunoglobin fusion protein (DART-Ig), a dual-variable domain immunoglobin (DVD-Ig), as well as an asymmetric IgG in which each arm engages a different epitope (e.g., Duobody or CrossMab).
