Table 3.

Traditional Cox Proportional Hazards Models and Subdistribution Models for Association of Weight Change with Central Body Fracture

	Hazard Ratio (95% CI)
	Weight Loss ≥10%	Weight Loss 5% to <10%	Stable Weight (Loss or Gain <5%)	Weight Gain ≥5%
Central body fracture (n=337)*	(N= 283)	(N= 742)	(N= 3,076)	(N= 422)
Age-adjusted Model
Cox proportional model	1.73 (1.16–2.59)	1.29 (0.98–1.70)	1.00 (referent)	1.03 (0.69–1.54)
Subdistribution model	1.24 (0.82–1.86)	1.16 (0.88–1.53)	1.00 (referent)	0.96 (0.65–1.44)
Base Model†
Cox proportional model	1.59 (1.06–2.38)	1.25 (0.95–1.65)	1.00 (referent)	1.02 (0.68–1.52)
Subdistribution model	1.16 (0.77–1.75)	1.14 (0.86–1.50)	1.00 (referent)	0.96 (0.64–1.43)
Base model + PASE
Cox proportional model	1.57 (1.05–2.36)	1.25 (0.95–1.65)	1.00 (referent)	0.99 (0.67–1.49)
Subdistribution model	1.15 (0.77–1.73)	1.13 (0.86–1.50)	1.00 (referent)	0.95 (0.63–1.41)
Base model + fall history
Cox proportional model	1.53 (1.02–2.29)	1.25 (0.95–1.65)	1.00 (referent)	1.00 (0.67–1.49)
Subdistribution model	1.12 (0.74–1.69)	1.13 (0.85–1.49)	1.00 (referent)	0.94 (0.63–1.40)
Base model + gait speed
Cox proportional model	1.51 (0.99–2.30)	1.20 (0.90–1.59)	1.00 (referent)	1.02 (0.68–1.52)
Subdistribution model	1.18 (0.78–1.80)	1.11 (0.83–1.47)	1.00 (referent)	0.99 (0.66–1.47)
Base model + femoral neck BMD
Cox proportional model	1.53 (1.03–2.29)	1.17 (0.89–1.55)	1.00 (referent)	1.01 (0.67–1.51)
Subdistribution model	1.02 (0.67–1.56)	1.04 (0.78–1.37)	1.00 (referent)	1.00 (0.66–1.49)

^*defined as hip, clinical vertebral or pelvis fracture

^†adjusted for age, race, smoking, and multimorbidity score