Figure 6. Salinomycin down-regulated hTERT and decreased telomerase activity.

Salinomycin and MST-312 treatments decreased telomerase activity. (A) HT-29 cells were treated with salinomycin alone or combined with MST-312, then was subject to western analyses of hTERT and pSTAT3 (B) HT-29 and SW480 cells were treated with 5-FU, Salinomycin, MST-312 and salinomycin and MST-312 combined, then applied to the telomerase activity assays. Data are presented as average ± SD (n=3 in each group) *p < 0.05, ** p < 0.01 ***, p < 0.001 vs. untreated control.