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. Author manuscript; available in PMC: 2017 May 10.
Published in final edited form as: Lab Anim (NY). 2013 Aug;42(8):292–300. doi: 10.1038/laban.255

FIGURE 3.

FIGURE 3

Ketoprofen blocks acid-induced depression of ICSS response rate. In the absence of lactic acid (LA vehicle), ketoprofen had no effect on ICSS response rate (a), but in the presence of lactic acid, pretreatment with 1.0 mg ketoprofen per kg body weight blocked the acid-induced depression of ICSS response rate (b) across a range of stimulation magnitudes (*P < 0.05). At a relatively high stimulation magnitude of 141 Hz, ketoprofen blocked acid-induced depression of ICSS response rate (thick arrow in b) but had no effect on response rate in the absence of lactic acid (thick arrow in a). However, these data at 141 Hz are not sufficient to show a lack of ketoprofen effect in the absence of acid, because baseline ICSS response rate at this stimulation magnitude was near maximal in the absence of acid and could not be further increased. Consequently, it is important to note that ketoprofen also failed to increase the lower baseline ICSS response rate maintained by a lower stimulation magnitude of 112 Hz in the absence of lactic acid (thin arrow in a). (c) Lactic acid significantly depressed total ICSS response rate across all stimulation magnitudes (#P < 0.05), and ketoprofen significantly blocked the acid-induced depression of ICSS response rate (*P < 0.05). Data adapted from ref. 40 and represent the mean ± s.e.m. of values from 4 rats.