TABLE 3.

Effects of different drug classes on acid-induced depression of ICSS response rate

Effective in blocking acid-induced depression of ICSS?	Class	Drug	References
Yes	NSAIDs	Ketoprofen	31,40
	μ-opioid agonists	Morphine, methadone, fentanyl, hydrocodone, buprenorphine, nalbuphine	30,41
	δ-opioid agonists	SNC80	42
	Dopamine reuptake inhibitors	Bupropion, cocaine, RTI112, RTI113	31,43
No	κ-opioid agonists	Salvinorin A, U69,593, ICI204448, ffir	31,53
	μ-, δ- and κ-opioid antagonists	Naltrexone, naltrindole, norbinaltorphimine	41,53,58
	Dopamine receptor antagonists	Flupenthixol	31
	Serotonin reuptake inhibitors	Citalopram, clomipramine	43
	Norepinephrine reuptake inhibitors	Nisoxetine, nortriptyline	43
	Serotonin and norepinephrine reuptake inhibitors	Milnacipran	43
	Cannabinoid receptor agonists	Δ9-tetrahydrocannabinol, CP55940	40