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. 2017 Feb 3;101(6):763–772. doi: 10.1002/cpt.567

Table 1.

Single‐nucleotide polymorphisms explored in the meta‐analysis

Gene dbSNP ID Nucleotide change Amino acid change MAFa Reference
OCT1 (SLC22A1) rs12208357 c.181C>T R61C 0.06 Shu et al., 200715; Shu et al., 200816; Tzvetkov et al., 200928; Zhou et al., 200919; Christensen et al., 201123
rs72552763 c.1260GAT>del M420del 0.1915, 45 Shu et al., 200715; Shu et al., 200816; Tzvetkov et al., 200928; Zhou et al., 200919; Christensen et al., 201123
rs622342 Intron A>C 0.38 Becker et al., 200920; Christensen et al., 201123
OCT2 (SLC22A2) rs316019 c.808G>T A270S 0.11 Song et al., 200829; Wang et al., 200830; Chen et al., 200917; Christensen et al., 201123; Tkáč et al., 201325
MATE1 (SLC47A1) rs2289669 Intron G>A 0.42 Becker et al., 200921; Tzvetkov et al., 200928; Jablonski et al., 201031; Christensen et al., 201123; Tkáč et al., 201325
rs2252281 g.‐66T>C 0.41 Stocker et al., 201318
MATE2‐K (SLC47A2) rs12943590 g.‐130G>A 0.27 Choi et al., 201124; Stocker et al., 201318
OCTN1 (SLC22A4) rs272893 c.917C>T T306I 0.41 Yoon et al., 201314
rs1050152 c.1507C>T L503F 0.39 Tzvetkov et al., 200928

Minor alleles are shown in bold. dbSNP, single nucleotide polymorphism database; ID, identification; MAF, minor allele frequency; MATE1, multidrug and toxin extrusion transporter; OCT1, organic cation transporter.

a

Minor allele frequencies from 1000 Genome Project Phase 3 EUR population (www.ncbi.nlm.nih.gov/projects/SNP).