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. 2017 Feb 3;101(6):763–772. doi: 10.1002/cpt.567

Table 6.

Meta‐analysis results for the effects of individual single‐nucleotide polymorphisms in the subgroups of patients homozygous for the wild‐type or variant allele of possible confounding single‐nucleotide polymorphisms ‐ interactions between metformin kidney transporters ‐ monotherapy group

Subgroup SNP Effect allele No. of studies No. of patients Beta SE P value I2 P(Q)
OCT2 A270S wt/wt MATE1 rs2289669 A 7 3,869 0.008 0.018 0.673 41.9 0.112
MATE1 rs2252281 C 5 1,835 ‐0.008 0.027 0.756 0.0 0.964
MATE2 rs12943590 A 7 3,176 ‐0.011 0.023 0.642 0.0 0.481
OCTN1 T306I T 7 3,642 0.030 0.019 0.118 0.0 0.660
OCTN1 L503F T 5 3,437 ‐0.040 0.019 0.034 0.0 0.720
OCT2 A270S v/v MATE1 rs2289669 A 3 59 0.045 0.210 0.831 0.0 0.950
MATE1 rs2252281 C 2 35 0.575 0.175 0.001 31.8 0.226
MATE2 rs12943590 A 3 48 0.170 0.337 0.615 0.0 0.557
OCTN1 T306I T 3 51 0.164 0.212 0.440 34.6 0.217
OCTN1 L503F T 3 50 ‐0.017 0.206 0.934 20.3 0.285
MATE1 rs2289669 wt/wt OCT2 A270S T 7 1,598 0.021 0.042 0.613 0.0 0.568
MATE2 rs12943590 A 7 1,288 ‐0.066 0.071 0.347 58.9 0.024
OCTN1 T306I T 7 1,412 0.044 0.054 0.418 63.4 0.012
OCTN1 L503F T 5 1,328 ‐0.069 0.029 0.015 0.0 0.884
MATE1 rs2289669 v/v OCT2 A270S T 6 495 ‐0.066 0.146 0.655 65.0 0.014
MATE2 rs12943590 A 7 363 0.065 0.052 0.215 0.0 0.529
OCTN1 T306I T 7 410 0.138 0.053 0.009 6.4 0.379
OCTN1 L503F T 5 365 ‐0.156 0.055 0.004 0.0 0.612
MATE1 rs2252281 wt/wt OCT2 A270S T 5 862 ‐0.014 0.056 0.802 0.0 0.942
MATE2 rs12943590 A 5 720 0.006 0.046 0.902 9.2 0.354
OCTN1 T306I T 5 726 ‐0.037 0.042 0.382 47.5 0.107
OCTN1 L503F T 4 662 ‐0.017 0.046 0.711 19.9 0.290
MATE1 rs2252281 v/v OCT2 A270S T 4 329 0.129 0.076 0.087 0.0 0.592
MATE2 rs12943590 A 5 276 ‐0.042 0.061 0.494 0.0 0.829
OCTN1 T306I T 5 283 0.013 0.067 0.853 22.1 0.274
OCTN1 L503F T 4 262 ‐0.011 0.074 0.884 0.0 0.650
MATE2 rs12943590 wt/wt OCT2 A270S T 7 1,964 0.001 0.036 0.978 22.4 0.259
MATE1 rs2289669 A 7 1,980 ‐0.010 0.023 0.673 0.0 0.454
MATE1 rs2252281 C 5 1,014 0.051 0.034 0.138 0.0 0.661
OCTN1 T306I T 7 1,828 0.043 0.026 0.095 39.7 0.127
OCTN1 L503F T 5 1,636 ‐0.050 0.027 0.062 26.4 0.246
MATE2 rs12943590 v/v OCT2 A270S T 7 298 ‐0.017 0.088 0.849 0.0 0.830
MATE1 rs2289669 A 7 300 0.183 0.115 0.112 51.3 0.055
MATE1 rs2252281 C 5 139 0.089 0.097 0.357 0.0 0.534
OCTN1 T306I T 7 279 ‐0.071 0.056 0.203 0.0 0.744
OCTN1 L503F T 5 241 0.080 0.058 0.168 0.0 0.455
OCTN1 T306I wt/wt OCT2 A270S T 7 1,806 0.081 0.041 0.048 0.0 0.557
MATE1 rs2289669 A 7 1,728 ‐0.020 0.028 0.469 0.0 0.554
MATE1 rs2252281 C 5 827 ‐0.001 0.040 0.976 35.2 0.187
MATE2 rs12943590 A 7 1,426 0.018 0.033 0.581 0.0 0.630
OCTN1 T306I v/v OCT2 A270S T 6 634 ‐0.017 0.067 0.803 31.7 0.198
MATE1 rs2289669 A 7 609 ‐0.023 0.040 0.571 25.7 0.232
MATE1 rs2252281 C 5 267 0.049 0.122 0.690 63.7 0.027
MATE2 rs12943590 A 7 541 ‐0.145 0.094 0.121 63.1 0.012
OCTN1 L503F wt/wt OCT2 A270S T 5 1,367 ‐0.040 0.047 0.394 41.8 0.143
MATE1 rs2289669 A 5 1,274 ‐0.019 0.031 0.548 0.0 0.724
MATE1 rs2252281 C 4 583 ‐0.059 0.063 0.344 42.2 0.158
MATE2 rs12943590 A 5 1,114 ‐0.049 0.057 0.394 53.5 0.072
OCTN1 L503F v/v OCT2 A270S T 5 816 0.106 0.063 0.095 40.2 0.153
MATE1 rs2289669 A 5 768 ‐0.042 0.045 0.354 0.0 0.982
MATE1 rs2252281 C 4 337 0.017 0.065 0.793 5.6 0.365
MATE2 rs12943590 A 5 584 0.031 0.053 0.561 0.0 0.857

A positive beta is a greater glycemic response to metformin associated with the effect allele.

I2, heterogeneity index; MATE, multidrug and toxin extrusion transporter; OCT1, organic cation transporter 1; P(Q), P value for Cochrane's Q statistic; SNP, single‐nucleotide polymorphism; v/v, homozygous variant allele carriers; wt/wt, homozygous wild‐type allele carriers.