Fig. 2.

A systems-based approach to understanding anthracycline-induced cardiotoxicity may consist of leveraging –omics technology to identify genomic transcripts (transcriptomics), proteins and protein modifications (proteomics), and metabolites (metabolomics) during acute treatment. Immune-omics may also be leveraged to study the role of immune interactions, which may alter cardiotoxic response. This panoply of data can be coupled with periodic longer-term imaging (based on exposure risk) to further identify those at the greatest risk of developing cardiac dysfunction