Table 2.
Summary of the effect of piperine and its analogs against tunicamycin (TM)-induced ER stress and cell death in NRK-52E cells
| Compound | Concentration tested | Cell viability | Western blotting | |
|---|---|---|---|---|
| GRP78 | CHOP | |||
| 4PBA (reference standard) |
1 and 2 mM | N.C | ▼ (~15%) | ▼ (~70%) |
| Piperine (PIP) |
250 and 500 nM | ▲ (~13%) | ▼ (~33%) | ▼ (~25%) |
| Piperic acid (PA1) |
250 and 500 nM | N.C | N.C | N.C |
| Cyclohexylamino analog (PA2) |
250 and 500 nM | ▲ (~11%) | ▼ (~25%) | ▼ (~30%) |
| Diethylamino analog (PA3) |
250 and 500 nM | N.C | N.C | ▲ (~69%) |
| Pyrrolidinyl analog (PA4) |
250 and 500 nM | ▲ (~11%) | N.C | N.C |
The black upward and downward pointing triangles indicate an increase and a decrease respectively in the parameter measured