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. 2017 May 9;112(9):1997–2010. doi: 10.1016/j.bpj.2017.03.022

Figure 3.

Figure 3

Rate-dependent effects of IKur block on the AP. (A) Shown here is the IKr activation gate steady state (xr,∞) as a function of test potential. V0.1, V0.5, V0.75, and V0.9 are marked and transposed onto (B) and (E) as dashed lines. (B) Shown here are APs obtained at a cycle length of 1000 ms under control (blue) and with 75% IKur blockade (red); the AP duration at −60 mV (APD−60) was 255 ms for both. (C and D) Shown here are corresponding IKur and IKr tracings; the ratio of IKr with 75% IKur block to control was 2.36. (E) Shown here are APs obtained at a cycle length of 250 ms under control (blue) and with 75% IKur blockade (red); the APD−60 for control and 75% IKur block was 199 and 209 ms, respectively. (F and G) Shown here are corresponding IKur and IKr tracings; the ratio of IKr with 75% IKur block to control was 1.40.