Fig. 3.

Schematic presentation of the allosteric signaling pathways between different domains of the AR or GR. Color code: light red DNA; light blue DBD; blue hinge; green NTD; orange LBD. 1 Signaling can take place between the DNA to the DNA-binding domain [17]; 2 between the DNA to the hinge [53]; 3 from the DNA to the amino-terminal domain [52, 63]; 4 from the DNA to the N/C interactions [63]; 5 from the DNA-binding domain to the ligand-binding domain [100]; and 6 between Tau-1 and Tau-5 [101]. For reasons of simplification, only allosteric pathways within one monomer are shown