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Changes in the sedation factor of the VAMS (mm, A), heart rate [in beats per min (b.p.m.), B], systolic (C) and diastolic (D) blood pressure (mm Hg) induced by public speaking in healthy volunteers. Points represent the means ± SEM of 11–12 subjects. Asterisks (∗) indicate statistically significant differences compared to the other groups, (&) indicates a significant difference compared to clonazepam, and ($) indicates a significant difference compared to the CBD-100 group.
