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. 2017 May 11;8:792. doi: 10.3389/fmicb.2017.00792

Figure 1.

Figure 1

Colonic and cecal disease is decreased in male and female mice rederived to GMCRL surrogate dams. Colon length of B6 (A) and C3H (B) IL-10−/− mice with differing gut microbiota profiles: GMCRL (Charles River Laboratories), GMJAX (The Jackson Laboratory), and GMTAC (Taconic); (n = 10 per group). Colon lesion score of B6 (C) and C3H (D) IL-10−/− mice with differing GM profiles (n = 15–25 per group). Cecal lesion score of B6 (E) and C3H (F) IL-10−/− mice with differing GM profiles (n = 15–25 per group). Colon length measured at time of necropsy from cecum to anus. Statistical significance determined by one way-ANOVA with Student Newman-Keuls post-hoc test. p ≤ 0.05 is significant. Colonic and cecal lesion scores based on severity and longitudinal extent of epithelial hyperplasia and inflammation (0 = no disease and 24 = most severe disease). Statistical significance of lesion scores and sex determined using two way-ANOVA with Student Newman-Keuls post-hoc test. Bars indicate mean and SEM. p ≤ 0.05 is significant. Statistical significance between groups annotated by same lower case letters above dot plots.