Table 4.
Statistical comparison of the relative abundance of OTUs between CMTR groups within the B6 IL-10−/− model.
| Significant OTUs in B6 IL-10−/− (CMTR to CD1 surrogates) | GMJAX relative to GMCRL | GMJAX relative to GMTAC | GMTAC relative to GMCRL | GMCRL | GMJAX | GMTAC | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Phylum | OTU | p-value | Mean fold change | p-value | Mean fold change | p-value | Mean fold change | Mean relative abundance (±SEM) | Mean relative abundance (±SEM) | Mean relative abundance (±SEM) |
| Bacteroidetes | Bacteroides acidifaciens | 0.002 | 3.260 | 0.620 | 1.16 | <0.001 | 2.809 | 0.022 ± 0.003 | 0.072 ± 0.013 | 0.062 ± 0.01 |
| Bacteroidetes | family Rikenellaceae | 0.006 | 0.458 | 0.003 | 0.446 | 0.979 | 1.027 | 0.095 ± 0.01 | 0.043 ± 0.014 | 0.100 ± 0.01 |
| Bacteroidetes | genus Bacteroides | <0.001 | 2.527 | 0.036 | 1.554 | 0.005 | 1.625 | 0.0834 ± 0.009 | 0.211 ± 0.306 | 0.136 ± 0.012 |
| Bacteroidetes | order Bacteroidales | 0.01 | 0.000 | 0.058 | 0.000 | 0.595 | 0.387 | 0.0002 ± 4.12E−05 | 0.000 ± 0.000 | 0.0001 ± 2.3E−05 |
| Deferribacteres | Mucispirillum schaedleri | 0.016 | 0.0005 | <0.001 | 0.0004 | 0.012 | 1.592 | 0.005 ± 0.0007 | 3.36E−06 ± 1.8E−06 | 0.008 ± 0.002 |
| Firmicutes | family Mogibacteriaceae | <0.001 | 0.374 | 0.032 | 0.564 | 0.005 | 0.662 | 0.0008 ± 0.00005 | 0.0003 ± 6.83E−05 | 0.0005 ± 6.9E−05 |
| Firmicutes | family Christensenellaceae | <0.001 | 2.858 | <0.001 | 2.332 | 0.691 | 1.226 | 0.0003 ± 0.00004 | 0.001 ± 0.0001 | 0.0003 ± 4.5E−05 |
| Firmicutes | family Clostridiaceae | 0.01 | 0.288 | 0.916 | 0.977 | 0.005 | 0.294 | 0.0001 ± 0.00024 | 0.0003 ± 6.04E−05 | 0.0003 ± 7.6E−05 |
| Firmicutes | genus Clostridium | 0.01 | 0.000 | 0.688 | 0.000 | 0.004 | 0.432 | 0.0005 ± 0.0001 | 0.000 ± 0.000 | 7.6E−05 ± 4.2E−06 |
| Firmicutes | genus rc4-4 | <0.001 | 0.035 | 0.044 | 0.088 | <0.001 | 0.402 | 0.0028 ± 0.0003 | 9.74E−05 ± 1.02E−06 | 0.001±.0002 |
| Firmicutes | order Clostridiales | <0.001 | 0.611 | 0.776 | 0.960 | <0.001 | 0.636 | 0.318 ± 0.015 | 0.19 ± 0.035 | 0.202 ± 0.015 |
| Proteobacteria | family Enterobacteriaceae | 0.002 | 21.629 | 0.006 | 24.616 | 0.974 | 0.879 | 8.93E−06 ± 3.3E−07 | 0.002 ± 0001 | 7.84E−06 ± 3.0E−06 |
| Proteobacteria | genus Helicobacter | <0.001 | 5.346 | <0.001 | 2.301 | 0.095 | 2.323 | 0.003 ± 0.0005 | 0.025 ± 0.005 | 0.007 ± 0.001 |
| TM7 | family F16 | 0.108 | 0.294 | 0.008 | 0.163 | 0.075 | 1.801 | 0.009 ± 0.001 | 0.002 ± 0.0008 | 0.016 ± 0.003 |
P-value, mean fold change, and mean relative abundance are shown. Statistical significance and interactions of GM profile, sex, and OTU were determined using two-way ANOVA with Student Newman-Keuls post-test. Bold face values indicate statistical significance (p ≤ 0.01).