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. 2017 May 11;11:89. doi: 10.3389/fnbeh.2017.00089

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Copyright © 2017 Faraji, Soltanpour, Ambeskovic, Zucchi, Beaumier, Kovalchuk and Metz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mutligenerational stress and cortical ischemic lesion alter hypothalamic-pituitary-adrenal (HPA) axis activity. (A) Multigenerationally stressed rats showed reduced levels of corticosterone (CORT) prior to focal cortical ischemia when compared with non-stressed rats. No between-group difference was observed in the post-ischemic measures of circulating CORT. (B) Multigenerational prenatal stress (MPS) elevated the Na/K ratio in hair, which reflects chronic adrenal gland malfunction. Asterisks indicate significant differences: *p < 0.05, **p < 0.01.