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. 2017 May 11;11:89. doi: 10.3389/fnbeh.2017.00089

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Copyright © 2017 Faraji, Soltanpour, Ambeskovic, Zucchi, Beaumier, Kovalchuk and Metz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Stress-induced microRNA and mRNA profiles. (A) Stress significantly down-regulated expression of the miR-708 in the prefrontal cortex. (B) Stress upregulated expression of Rasd2 and Mapk10 genes. (C) Illustrative image showing pathways altered by the miR-708. Specifically, miRNA targets five genes (Map3k13, Mapk10, Kras, Rap1b, Nras, Rasd2 and Csf1) which directly affect mitogen activated protein kinase (MAPK) signal pathways, ultimately altering the neuronal development and the regulation of cell proliferation. Asterisks indicate significant differences: *p < 0.05, *** adjusted p < 0.001, ^#indicates near significance.