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. 2016 Mar;23(10):1062–1081. doi: 10.2174/0929867323666160304150522

Table 1.

Multiple drug-resistant (MDR) bacterial pathogens that are causing major problems in clinic.

Pathogen Clinical settings and resistance headlines
Enterococcus faecium Bloodstream, surgical site and urinary tract infections (UTI)
Staphylococcus Aureus Skin and wound infections, pneumonia, bloodstream infections
Klebsiella pneumoniae Bloodstream, UTI, catheter-related infections, ventilator associated pneumonia (VAP).
Major issues with resistance to carbapenems; notably through emergence of “Klebsiella pneumoniae carbapenemase” (KPC) producing isolates
Acinetobacter baumannii Bloodstream infections, wounds, VAP
At least 63% of Acinetobacter isolates are resistant to >3 classes of front-line antibiotic.
Pseudomonas Aeruginosa Bloodstream, urinary tract and surgical site infections, pneumonia (cystic fibrosis), VAP
~13% of Pseudomonas isolates are resistant to >3 classes of front-line antibiotic.
Enterobacter sp Bloodstream, UTI, catheter-related infections,
Escherichia coli Bloodstream, urinary tract and surgical site infections, pneumonia (cystic fibrosis)
Burkholderia cepacia / cenocepacia Cystic fibrosis, VAP
Intrinsically drug resistant and becoming a major problem in conjunction with other pathogens in the lung
Stenotrophomonas maltophilia Various
Intrinsically drug resistant and associated with infections in a number of hospital settings.