Table 2.

Proteins involved in PMDs, and their interactions with RNA and/or DNA molecules

Protein	DNA	Effect	Refs.	RNA	Effect	Refs.
PrP	+	Aggregation inhibition or induction; conversion into β-sheet-rich species that may be cytotoxic.	Cordeiro et al. 2001; King et al. 2007; Macedo et al. 2012; Cavaliere et al. 2013	+	Aggregation inhibition or induction; conversion into β-sheet-rich species; generation of cytotoxic species.	Deleault et al. 2003; Gomes et al. 2008a, b; Mashima et al. 2009
tau	+	Binding stabilizes the dsDNA molecule.	Vasudevaraju et al. 2012; Hua and He 2003; Qu et al. 2004	+	Aggregation is enhanced in vitro by RNA molecules.	Kampers et al. 1996
Aβ	+	Aβ fibrils bind DNA; interactions alter DNA conformation.	Yu et al. 2007; Maloney and Lahiri 2011; Camero et al. 2013b	+	Modulation of peptide aggregation.	Ahn et al. 2000; Takahashi et al. 2009
α-syn	+	Induction of α-syn assembly into mature fibrils; folding of α-syn.	Cherny et al. 2004; Hegde and Rao 2007	-	Not reported.
Htt	+	Alters DNA conformation.	Benn et al. 2008	-	Not reported.