Figure 1.
MSCs and MSC-derived EVs Delay the Onset of T1D in Mice
(A) Experimental scheme. On day 0, MSCs (1 × 106 cells), EVs (3 μg or 30 μg), or vehicle control were intravenously (IV) infused immediately after injection of splenocytes from diabetic NOD mice into NOD/scid mice. On day 4, MSCs, EVs, or vehicle control were infused again. Mice were monitored for hyperglycemia.
(B) Diabetes incidence. PBS (n = 18); 3 μg EVs (n = 8); 30 μg EVs (n = 10); HBSS (n = 10); MSCs (n = 10). p Value by Kaplan-Meier estimator.