FIG 1 .
Detection of ISZ. (A) Chemical structure of ISZ. The chemical formula is C22H17F2N5OS, with a molecular mass of 437.47 g/mol. (B) Chromatogram on filtered pooled human plasma spiked with ISZ and prepared according to the instruction manual for the TDM kit. For improved visualization the red and blue lines were transformed by adding 1.5 and 3.0 million counts, respectively, to the measured values at all time points. A clear symmetric peak for ISZ appears in the chromatogram, with a retention time around 12.1 min. I.S., internal standard.