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Two-site binding model (referred to as the hinge and latch model) of Keap1 and Nrf2. Left Under homeostatic conditions, the Keap1 homodimer binds to a single Nrf2 chain at two sites of the Kelch domain monomers and recognises the DLG and ETGE motifs in Nrf2 simultaneously. Right Under stress conditions, conformational changes occur in the Keap1 homodimer, which subsequently disrupt the weakly binding DLG motif interaction with the Kelch domain
