Table 3.
Mismatches between donor and recipient observed in the non-ARD-encoding exons
| Allele 1 | Allele 2 | No. Observed | Location of Variation Exon/Codon AA Substitution/Location in Proteina |
CWD Status of Allele 2b |
|---|---|---|---|---|
| A*01:01:01:01 | A*01:37 | 1 | Exon 4/T228M/α3 | Not CWD, confirmed by Sanger |
| A*03:01:01:01 | A*03:26 | 1 | Exon 4/K268E/α3 | WD, confirmed by Sanger |
| B*27:05:02 | B*27:13 | 1 | Exon 1/A-20E/leader | Not CWD; GenBank: KX686520 (*27:13) |
| B*40:01:02 | B*40:01var GenBank: KX686514 |
1 | Exon 4/265 synonymous | Novel, confirmed by Sanger |
| B*44:02:01:03 | B*44:27:01 | 1 | Exons 4,5,7/V199A, V282I, A305T, C325S/α3, TM, Cyt | Common |
| B*51:01:01 | B*51:11N | 1 | Exon 4/185 insertion/not expressed | WD |
| C*03:03:01 | C*03:03var GenBank: KX686519 |
1 | Exon 5/P276L/TM | Novel |
| C*04:01:01 | C*04:09N | 2 | Exon 7/341 deletion/not expressed | Common |
| C*04:01:01 | C*04:01var GenBank: KX686516 |
1 | Exon 1/−5 Synonymous | Novel |
| C*07:01:01:01 | C*07:18 | 1 | Exon 6/A324V/cyt | Common |
| DRB1*14:01:01 | DRB1*14:54:01 | 2 | Exon 3/Y112H/β2 | Common |
| DQA1*03:01:01 | DQA1*03:03:01 | 2 | Exon 3/A160D/α2 | Common |
| DQA1*04:01:01 | DQA1*04:02 | 1 | Exon 3/T138I/α2 | Not CWD |
| DQA1*05:05:01 | DQA1*05:09 | 1 | Exon 1/E1K/α1 | WD |
a
TM, transmembrane; Cyt, cytoplasmic tail
b
[19]; CWD, common or well documented