Fig. 3.
Distribution of R 2 of BSLMM for the Geuvadis data. a A Manhattan-type plot shows R 2 and gene positions across chromosomes, in which the y-axis is R 2 for each gene, the x-axis is the gene position and the various colors represent different chromosomes. b The barplot shows the proportion of predictive genes (R 2 ≥ 0.05) for each chromosome. c The scatter of the proportion of the predictive genes against the proportion of gene in each chromosome. d The R 2 pattern for the MHC region (chr6: 26-34 Mb); there are a total of 179 genes with R 2 ≥ 0.05 in chromosome 6, among which 45 are located on the MHC region (in red). The total length of chromosome 6 is about 171 Mb, and the length of the MHC region is 8 Mb. Then the enrichment-fold is 5.37, which is computed as the ratio of the proportion of predictive genes (i.e. 0.25 = 45/179) and the proportion of the length of MHC (i.e. 0.05 = 8/171), and is significantly higher (P = 1.79 × 10−3) than the average enrichment-fold (the median is 1.70) of other regions in chromosome 6