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. 2016 Jun 15;2(1):vew015. doi: 10.1093/ve/vew015

Figure 1.

Figure 1.

Lineage relationships of EV-D68 isolates inferred from VP1 phylogeny. (A) A phylogenetic tree of all available full-length VP1 nucleotide sequences as of 9 February 2016 in ViPR. The tree was constructed using RAxML and is color-coded by year of isolation (e.g. 2013: blue; 2014: red; 2015: green). Syntax for tree leaf labels is: strain name|isolation date|isolation country. Bootstrap support values are shown for all major branching nodes. Clade classifications are based on bootstrap values of 100 percent. Three major clades (A, B, and C) are present ( Tokarz et al. 2012), with clade B split into subclades B1 and B2. (B) A close-up of subclade B1. Isolates associated with AFM/AFP and encephalitis (Greninger et al. 2015) are marked with an asterisk and a plus sign, respectively.