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. 2017 Apr 29;12:916–928. doi: 10.1016/j.redox.2017.04.035

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1. — NNT deficiency reduces proliferation and tumorigenesis of hepatoma. (A) Expression of NNT, porin and actin of cell lysate and mitochondria fraction in SK-shNNT and SK-Sc cells analyzed by immunoblotting. (B) Growth curves of SK-shNNT and SK-Sc cells. Data are mean±SD, n=6. ** p<0.01 *** p<0.005 vs. SK-Sc cells at indicated time. (C) Colonies formed by SK-shNNT and SK-Sc cells were rated according to their diameters. Data are mean±SD, n=9. * p<0.05, vs. SK-Sc cells. (D) The tdTomato fluorescent signal of tumors formed by Tomato-SK-shNNT and Tomato-SK-Sc cells at 10th week after injection. (E) Temporal change in tumor fluorescence during tumor growth. Data are mean±SD, n=34. ^# p<0.05, * p<0.005, vs. Tomato-SK-Sc cells. (F) The tumors were retrieved from cell-injected mice, and weighed at 10th week after implantation. Data are mean±SD, n=34. * p<0.05, vs. Tomato-SK-Sc cells.