Fig. 2.

TMS simulations. A) Decay of the field strength underneath the coil centre with increasing stimulation depth. The results for patient P01 are compared with those of the healthy control. Mean curves averaged across both coil orientations and for groups of positions with similar distances to the lesion centre are shown. Top left: Results for the position directly above the lesion centre (indicated in green on the head model). Top right: Average of all positions directly neighbouring the lesion site (light blue spheres on the head model). Bottom left: Average of all positions distant to the lesion site (dark blue spheres on the head model). The vertical lines indicate the standard deviation. For none of the distances, a systematic difference between the results obtained for patient P01 and the healthy control is seen. B) Decay of the field strength with depth for patient P02, averaged across all nine positions and both coil orientations. The results are very similar to those of the healthy control. C) Sagittal cut through the head model of patient P01. The coil was positioned above the lesion centre (the green dots indicate a line perpendicular to the coil plane and starting at the coil centre) and the current orientation was anterior-posterior. The position at the lesion boundary highlighted by the red arrow experiences high field strengths, despite being distant to the coil centre. This effect is caused by the anterior-posterior currents induced in the lesion cavity which hit the gyrus approximately perpendicularly. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)