Table 1.
HMGB1 and other biomarkers of patients with ovarian cancer treated with peptide vaccination†.
| Case | Overall survival (months) |
IgG response | CTL response | Epitope spreading | HMGB1‡ (ng/mL) |
MDSC‡ (%) | SAA‡ (mg/dL) | CRP‡ (mg/dL) | IL-6‡ (pg/mL) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pre | Post | Pre | Post | Pre | Post | Pre | Post | Pre | Post | ||||||||||
| F-018 | 19.1 | No | No | No | <2.5 | 2.7 | NC | 0.3 | 0.6 | I | 10.5 | 5.2 | D | 0.3 | 0.4 | NC | 2 | 11 | I |
| FOV-003 | 20.0 | Yes | Yes | Yes | 5.9 | <2.5 | D | 0.2 | 0.3 | NC | 1.5 | 19.5 | I | 0.0 | 0.9 | I | 0 | 0 | NC |
| FOV-004 | 5.3 | Yes | Yes | Yes | 10.6 | <2.5 | D | 0.6 | 0.5 | NC | 3.2 | 11.6 | I | 0.1 | 0.3 | I | 2 | 3 | NC |
| FOV-005 | 11.4 | Yes | Yes | Yes | 5.7 | <2.5 | D | 0.6 | 0.5 | NC | 0.4 | 12.7 | I | 0.2 | 0.8 | I | 0 | 2 | I |
| FOV-006 | 34.7 | Yes | Yes | Yes | <2.5 | 2.9 | NC | 0.5 | 0.5 | NC | 0.7 | 1.1 | NC | 0.1 | 0.2 | I | 0 | 0 | NC |
| FOV-008 | 14.1 | Yes | Yes | No | 4.3 | 2.8 | NC | 0.1 | 0.1 | NC | 2.4 | 18.8 | I | 0.1 | 0.9 | I | 0 | 0 | NC |
| FOV-009 | 8.1 | Yes | Yes | Yes | 4.5 | 3.9 | NC | 0.5 | 0.4 | NC | 20.4 | 20.8 | NC | 0.7 | 1.0 | NC | 0 | 0 | NC |
| FOV-010 | >69.7 | Yes | Yes | Yes | <2.5 | <2.5 | NC | 0.1 | 0.3 | I | 0.3 | 7.9 | I | 0.0 | 0.5 | I | 0 | 0 | NC |
| FOV-012 | 16.1 | Yes | Yes | No | <2.5 | <2.5 | NC | 1.1 | 1.6 | NC | 6.3 | 1.7 | D | 0.1 | 0.5 | I | 0 | 0 | NC |
| FOV-013 | 4.0 | No | Yes | No | <2.5 | 3.7 | NC | 0.1 | 0.1 | NC | 11.8 | 11.8 | NC | 0.9 | 0.9 | NC | 10 | 23 | I |
| FOV-014 | 32.2 | Yes | Yes | Yes | 5.0 | 3.5 | NC | 0.3 | 0.3 | NC | 12.8 | 14.8 | NC | 0.1 | 0.3 | I | 0 | 0 | NC |
| FOV-015 | 10.7 | Yes | No | No | 4.0 | 10.4 | I | 1 | 1.2 | NC | 2.9 | 14.9 | I | 0.6 | 0.9 | NC | 0 | 0 | NC |
| FOV-016 | 29.5 | Yes | Yes | No | 3.8 | 9.2 | I | 0.6 | 0.4 | NC | 12.1 | 13.8 | NC | 1.0 | 0.9 | NC | 6 | 12 | I |
| FOV-019 | >61.3 | Yes | No | Yes | 2.7 | 4.9 | NC | 0.6 | 0.4 | NC | 1.4 | 5.6 | I | 0.1 | 0.6 | I | 0 | 0 | NC |
| FOV-022 | 22.0 | Yes | Yes | No | 4.6 | 3.2 | NC | 0.5 | —§ | 1.8 | 3.6 | I | 0.4 | 0.1 | D | 0 | 0 | NC | |
| FOV-023 | 16.8 | Yes | Yes | Yes | 6.5 | 3.5 | NC | 0.1 | 0.2 | I | 13.8 | 11.9 | NC | 1.5 | 2.3 | NC | 2 | 15 | I |
| FOV-024 | 8.7 | No | No | No | <2.5 | 6.1 | I | 0.2 | 0.1 | D | 8.9 | 11.8 | NC | 0.8 | 2.3 | I | 0 | 17 | I |
| FOV-026 | >45.7 | Yes | Yes | Yes | 3.1 | 5.2 | NC | NC | 4.2 | 5.5 | NC | 0.1 | 0.1 | NC | 0 | 0 | NC | ||
| FOV-027 | 36.9 | Yes | Yes | Yes | 12.8 | 7.8 | NC | 0.2 | 0.6 | I | 2.6 | 4.8 | NC | 0.0 | 0.6 | I | 0 | 0.5 | I |
| FOV-028 | >42.7 | Yes | Yes | No | 17.4 | <2.5 | D | 0.2 | 0.7 | I | 0.3 | 0.4 | NC | 0.3 | 0.0 | D | 1.2 | 1.1 | NC |
| FOV-030 | 22.0 | Yes | Yes | Yes | 8.5 | 12.5 | NC | 0.4 | 0.5 | NC | 6.1 | 22.5 | I | 0.4 | 4.1 | I | 0 | 8 | I |
| FOV-031 | 19.6 | Yes | No | Yes | 4.2 | 4.7 | NC | 0.3 | 0.3 | NC | 8.2 | 9.5 | NC | 0.1 | 0.2 | I | 0 | 0 | NC |
| FOV-032 | 12.6 | Yes | Yes | Yes | 4.2 | 3.8 | NC | 0.6 | 0.3 | D | 0.3 | 5.2 | I | 0.2 | 2.2 | I | 0 | 7.2 | I |
| FOV-033 | 26.9 | Yes | Yes | Yes | <2.5 | 3.5 | NC | 0.4 | 0.5 | NC | 1.6 | 12.9 | I | 0.1 | 1.8 | I | 0 | 2.7 | I |
| FOV-034 | 26.8 | Yes | No | Yes | 12.2 | 6.7 | NC | 0.7 | 0.6 | NC | 0.6 | 0.7 | NC | 0.1 | 0.3 | I | 0 | 0 | NC |
| FOV-036 | 24.0 | Yes | Yes | Yes | 5.4 | 4.2 | NC | 0.2 | 0.2 | NC | 1.8 | 19.3 | I | 1.9 | 4.4 | I | 0.9 | 26.2 | I |
| FOV-037 | 4.6 | No | No | No | 7.3 | 2.6 | D | 0.7 | 0.4 | NC | 0.7 | 15.8 | I | 1.4 | 4.4 | I | 4.6 | 19.8 | I |
| FOV-038 | 7.9 | No | No | No | 15.1 | 18.6 | NC | 1.4 | 1.1 | NC | 11.6 | 20.9 | NC | 1.7 | 3.6 | I | 4.5 | 14.9 | I |
| FOV-039 | >10.3 | Yes | No | No | 3.0 | <2.5 | NC | —§ | 0.9 | 1.3 | NC | 0.4 | 0.7 | NC | 0 | 1.6 | I | ||
| FOV-040 | 2.2 | No | No | No | 6.1 | <2.5 | D | 0.8 | 0.6 | NC | 14.1 | 15.5 | NC | 1.0 | 1.8 | NC | 3.9 | 7.2 | NC |
| FOV-041 | 18.3 | Yes | No | Yes | 8.6 | 3.6 | D | 0.8 | 0.5 | NC | 2.1 | 2.3 | NC | 0.1 | 0.1 | NC | 0 | 0 | NC |
| FOV-042 | >37 | Yes | No | No | 4.0 | 4.0 | NC | 0.3 | 0.1 | D | 0.3 | 0.4 | NC | 0.1 | 0.1 | NC | 0 | 0 | NC |
| FOV-043 | 29.2 | Yes | Yes | Yes | 2.9 | 4.6 | NC | 0.2 | 0.3 | NC | 13.4 | 1.3 | D | 2.0 | 0.3 | D | 12.5 | 0 | D |
| FOV-044 | 19.6 | Yes | Yes | Yes | 10.4 | 2.9 | D | 0.1 | 0.2 | I | 1.0 | 10.1 | I | 0.0 | 1.3 | I | 0 | 0 | NC |
| FOV-045 | 8.3 | Yes | Yes | Yes | 6.3 | 5.5 | NC | 0.2 | 0.3 | NC | 1.6 | 18.8 | I | 0.7 | 3.6 | I | 1.8 | 10.7 | I |
| FOV-046 | 6.6 | Yes | Yes | No | 3.7 | <2.5 | NC | 0.3 | 0.1 | D | 21.0 | 16.0 | NC | 3.8 | 4.1 | NC | 11.4 | 17.1 | NC |
| FOV-047 | >35.5 | Yes | Yes | Yes | 8.7 | 3.8 | D | 0.5 | 0.8 | NC | 6.3 | 1.6 | D | 0.4 | 0.2 | D | 16.3 | 1.4 | D |
| FOV-048 | 4.7 | Yes | No | No | 7.0 | <2.5 | D | 0.5 | 0.3 | NC | 21.9 | 18.3 | NC | 3.9 | 4.9 | NC | 2.1 | 17.6 | I |
| FOV-049 | 22.0 | Yes | No | Yes | 6.6 | 4.8 | NC | 1 | 0.7 | NC | 4.2 | 2.6 | NC | 0.2 | 0.4 | I | 0 | 0 | NC |
† ‡ §Blood samples of patients were collected before (pre) and after (post) the 1st cycle of vaccination, and HMGB1 and other biomarkers were measured. Response criteria of IgG, CTL, and epitope spreading were previously reported; post values were compared with prevalues, and if the postvalue was ≥150% or ≤50% of prevalue, it was considered increased or decreased, respectively. I: increased; D: decreased; NC: no change; samples were not available.