Table 2.
Comparison of HMGB1 and other biomarkers.
| IgG response |
CTL response |
Epitope spreading |
MDSC increase |
SAA increase |
CRP increase |
IL-6 increase |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n = 39 | n = 39 | n = 39 | n = 37 | n = 39 | n = 39 | n = 39 | ||||||||
| n | n | n | n | n | n | n | ||||||||
| HMGB1 increase (I) | Yes | 2 | Yes | 1 | Yes | 0 | Yes | 0 | Yes | 1 | Yes | 1 | Yes | 2 |
| No | 1 | No | 2 | No | 3 | No | 3 | No | 2 | No | 2 | No | 1 | |
| HMGB1 no change (NC) | Yes | 23 | Yes | 18 | Yes | 17 | Yes | 4 | Yes | 9 | Yes | 16 | Yes | 11 |
| No | 3 | No | 8 | No | 9 | No | 20 | No | 17 | No | 10 | No | 15 | |
| HMGB1 decrease (D) | Yes | 8 | Yes | 6 | Yes | 6 | Yes | 2 | Yes | 5 | Yes | 5 | Yes | 3 |
| No | 2 | No | 4 | No | 4 | No | 8 | No | 5 | No | 5 | No | 7 | |
| p value† | ||||||||||||||
| I versus not I (NC+D) | 0.3698 | 0.2475 | 0.0307∗ | 0.4267 | 0.8493 | 0.4015 | 0.3473 | |||||||
| D versus not D (NC+I) | 0.639 | 0.7538 | 0.939 | 0.7039 | 0.3844 | 0.6355 | 0.4111 | |||||||
|
| ||||||||||||||
| MDSC decrease |
SAA decrease |
CRP decrease |
IL-6 decrease |
|||||||||||
| n = 37 | n = 39 | n = 39 | n = 39 | |||||||||||
| n | n | n | n | |||||||||||
|
| ||||||||||||||
| HMGB1 increase (I) | Yes | 1 | Yes | 0 | Yes | 0 | Yes | 0 | ||||||
| No | 2 | No | 3 | No | 3 | No | 3 | |||||||
| HMGB1 no change (NC) | Yes | 3 | Yes | 3 | Yes | 2 | Yes | 1 | ||||||
| No | 21 | No | 23 | No | 24 | No | 25 | |||||||
| HMGB1 decrease (D) | Yes | 0 | Yes | 1 | Yes | 2 | Yes | 1 | ||||||
| No | 10 | No | 9 | No | 8 | No | 9 | |||||||
| p value | ||||||||||||||
| I versus not I (NC+D) | 0.19 | 0.5422 | 0.5422 | 0.6751 | ||||||||||
| D versus not D (NC+I) | 0.1975 | 0.9753 | 0.2389 | 0.418 | ||||||||||
† ∗ p values of chi-square test are shown; statistically significant.