Table 3.
Regions significant for a main effect of group (recurring-episode MDD, resilient MDD, HC group) for functional connectivity to the left anterior subgenual cingulate cortex seed region
| Hemisphere | Regions | Peak MNI coordinates | Peak Z score | Cluster size | FWE-corrected p | ||
|---|---|---|---|---|---|---|---|
| x | y | z | |||||
| R | Anterior subgenual cingulate cortex | 9 | 21 | −12 | 4.03 | 22 | 0.039 a , b |
| L | Posterior subgenual cingulate cortex | −6 | 15 | −3 | 3.20 | 4 | 0.043 c , d |
MDD, Major depressive disorder; HC, healthy control; MNI, Montreal Neurological Institute; FWE, family-wise error; R, right; L, left; ROI, region of interest; s.d., standard deviation; CI, confidence interval.
FWE-corrected at the cluster level over an a priori ventromedial prefrontal cortex ROI.
Lower connectivity with the seed region in the resilient MDD patients (mean = 0.31, s.d. = 0.14) compared with both the recurring-episode MDD (mean = 0.42, s.d. = 0.15, p = 0.013, mean difference = −0.12, 95% CI −0.22 to −0.02, d = 0.76) and HC groups (mean = 0.48, s.d. = 0.12, p < 0.0001, mean difference = −0.17, 95% CI −0.25 to −0.09, d = 1.30).
FWE-corrected at the cluster level over an a priori septal region ROI.
Lower connectivity with the seed region in the resilient MDD patients (mean = 0.61, s.d. = 0.22) compared with the HC group (mean = 0.81, s.d. = 0.18, p < 0.0003, mean difference = −0.20, 95% CI −0.31 to −0.08, d = 1.00) but not the recurring-episode MDD group (mean = 0.71, s.d. = 0.19, p = 0.29, mean difference = −0.10, 95% CI −0.24 to 0.04, d = 0.49).